While single cell studies have historically been the driving force for cell biology, collective, or group, behavior is actually the true working mechanism of numerous growth and pathological phenomenon in the body including morphogenesis, wound healing, and cancer metastases. Mechanical micro-environment cues have been demonstrated as important regulators of single cell behavior, and this project focuses on investigating mechanical regulation of collective cell behavior via microtopographic substrates.
Project end date: 08/15/12