BioMEMS

Research that includes:

  • Immunosensors
  • Single Cell Analysis
  • Cell Manipulation and Probing
  • SERS BioImaging
  • Micro Total Analysis Systems uTAS
  • DNA Transformations
  • Cell Cryropreservation
  • Optoelectronic Transport & Tweezers

LPL13: Vertically-Integrated Micro Confocal Imaging Array (VIµ-CIA)

Sunghoon Kwon
2003

The goal of this project is development of MEMS laser scanning confocal microscopes for multiplexed Lab-On-A-Chip applications. The hybrid integration of microfabricated microlens scanner and confocal pinhole, laser diodes, and photodiode allows to create handheld sized autonomous confocal excitation and detection microsystem. Without use of bulky external microscopes, we have successfully demonstrated laser induced fluorescent excitation and detection from multiple of microfluidic channels and reflectance image reconstruction using the developed system.

Project end...

LPL29: Nanoprobes for Monitoring Sub-cellular Response to Localized Surface Interactions

Philip J. Lee
2004

We are developing devices with nanoscale features for the analysis of real time cell response to localized stimulation. This enables the tracking of signaling molecules to/away from the site of interaction. Monitoring of cell behavior will be useful for biosensors, tissue engineering, and single cell manipulation.

Project end date: 02/12/04

LWL10: An Integrated Polypyrrole/Carbon Nanotube (PPy/MWNT) Nanocomposite Glucose Sensor

Kwok-Siong Teh
2004

The ultimate goal is to develop an enzymatic and mediatorless glucose sensor, which can be integrated with micro-osmotic pumps, micro-valves, micro-accumulators and microneedles, to form a continuous-flow bioassay system.

Project end date: 08/18/04

DL14: Simulation of Laser Heating in Microchannels Utilizing CFDRC

David Mun
2004

With the recent rapid advancements in computer technology, increasingly complex and powerful simulation programs are being developed that allow engineers and scientists in a variety of disciplines to develop extremely sophisticated and detailed models which simulate phenomena that might otherwise be difficult or impossible to verify experimentally or analytically. One specific application of this new technology is in the area of computational fluid dynamic (CFD) simulations. CFD simulations hold the potential to be utilized in a myriad of situations, from jet turbines modeling to...

DL/LWL1: Microneedle-based minimally invasive continuous glucose monitor

Stefan Zimmermann
Boris Stoeber
Doerte Fienbork
2004

The capability to easily and continuously monitor the blood glucose level would be a tremendous improvement in the treatment of diabetes. A painless approach is to measure the glucose level of the interstitial fluid, which correlates well with the blood glucose level. Long-term goal of this project is the development of a disposable minimally invasive self-calibrating continuous glucose monitor consisting of hollow out-of-plane microneedles to sample interstitial fluid from the epidermis, an integrated dialysis membrane and an integrated electrochemical enzyme-based flow-through...

DL15/APP: A planar micropump utilizing thermopneumatic actuation and in-plane flap valves

Stefan Zimmermann
Jeremy Frank
2004

Development of a planar micropump for integration in a planar microfluidic mixer.

Project end date: 08/18/04

LPL11: Integrated Polymer Actuators in Microfluidic Systems

Nikolas Chronis
2004

To develop polymer-based actuators that can operate inside microfluidic systems and investigate their capabilities and limitations.

Project end date: 08/18/04

LPL18: Nanopillar Substrate for Surface-Enhanced Raman Spectroscopy

Gang L. Liu
2004

Nanopillar structures are fabricated in batch process with controllable geometry and pattern. After metallization, nanopillars will be used as Raman signal enhancing substrate. Through the surface modification of substrate with differently patterned nanopillars and the incorporation with micro/nano fluidics and MEMS scanning optics, high-sensitivity multiplexed biomolecule recognitions by SERS can be realized on a chip.

Project end date: 08/18/04

LPL20: A new pressure tranduction mechanism using elastomer micromolding

Cristian Ionescu-Zanetti
2004

Local on-chip pressure sensing is an important application of micro-electro-mechanical devices. Traditionaly, sensing has been done based on either piezoelectric material properties or capacitance measurements across a micromachined cavity.

Project end date: 08/18/04

LPL28: Microfluidic-Based Two-Dimensional Protein Chip

Paul Hung
2004

Demonstration of a microfluidic device at a size of 3”x3” for two-dimensional separation of proteins. The goal is to provide a better tool for proteomics research with faster turnaround time, less reagent consumption, less bio-waste production, as well as better resolution to distinguish similar biomolecules.

Project end date: 08/30/04