Artificial 3D architectures of collagen fibers using microfabricated polymer structures has exciting medical applications. Aligned collagen matrices more closely resemble tissues found in nature. Collagen alignment may prove beneficial for tissue regeneration, show enhanced mechanical properties, and serve as a biomimetic material. Moreover, the basic biophysical characterizations of aligned collagen fibrils will provide an insight for the mechanism of electrical signal transductions and electromechanical actuations of our tissues.
Project end date: 08/27/03