Research that includes:

  • Immunosensors
  • Single Cell Analysis
  • Cell Manipulation and Probing
  • SERS BioImaging
  • Micro Total Analysis Systems uTAS
  • DNA Transformations
  • Cell Cryropreservation
  • Optoelectronic Transport & Tweezers

BPN890: Hydrogel Actuated Carbon Fiber Microelectrode Array

Oliver Chen

Glial scarring and passivization of long-term implanted neural probes is one bottleneck in brain- machine interface technology. However, ultraflexible probes with similar mechanical properties as tissue have been shown to minimize scarring and other biological responses. We propose a flexible, microscale neural probe that can be actuated using an expanding hydrogel. This device is designed to be able to record neural signals up to hundreds of microns away from the insertion site. This design can allow for high-density, accurate neural recordings for a wide variety of clinical applications...

Oliver Chen

Graduate Student Researcher
Electrical Engineering and Computer Sciences
Professor Michel M. Maharbiz (Advisor)
Ph.D. 2022 (Anticipated)

Oliver graduated with the B.S. degree in Electrical Engineering from the California Institute of Technology in 2016. He is currently working on hydrogel actuated carbon fiber microelectrode arrays in as an EECS PhD student at the University of California, Berkeley with Prof. Michel Maharbiz. He is a recipient of the NSF Graduate Research Fellowship.

Oliver is interested in biomedical device technology related to both systems-level design and MEMS devices. This includes microfabrication and implementation of implantable devices, in particular, neural probes for brain-machine...

BPN924: Multimodality Platform for Neurogenesis and Neural Signal Recording After Stroke

Wentian Mi

Stroke is a leading cause of disability in the United States. Recovery from stroke is complex and ultimately limited by the brains limited ability to regenerate damaged tissue. Ideally, we would want to drive neurogenesis and angiogenesis in a stroke lesion to aid in recovery. We propose a multimodality platform for stimulating neurogenesis which simultaneously allows for electrophysiological recording of neurons in the lesion area after stroke. Our aim is to provide a paradigm for making complex substrates for nervous tissue. With various devices integrated, multiple functions can be...

BPN894: Acoustically-Driven, Electrically-Controlled Microswimmer

Mauricio J. Bustamante

Underwater self-powered micro-swimmers have several biomedical and environmental applications, such as drug delivery and pathogen elimination in water. Therefore, there is a need for propulsion mechanisms that operate well in the low Reynolds number regimen. We propose a mechanism that uses resonating water-air interfaces to generate underwater propulsion, and electrolysis as a control mechanism. This way, an external field can be used as a power source while control occurs at the device level. It is known that, when actuated by ultrasound waves near its resonance frequency, a bubble...

BPN948: Wireless Tactile Stimulation with MEMS Inchworm Motors

Dillon Acker-James

The goal of this project is to make an untethered MEMS tactile stimulator. Electrostatic inchworm motors made in SOI substrates routinely generate 1-15 mN of force and 2 mm/s travel, making them a viable option for a millimeter-scale wireless tactile stimulator. Collaborating with Professor Eric Paulos and his students, our first step is to conduct haptic sensation surveys in order to understand what a user feels based on different forces. Our current chips provide a force range of 1mN up to 15mN, but we plan to increase this in the future. Our next step would be to integrate the MEMS...

APP68: Plastic Injection Molded Microneedles

Jonathan Fischer

The objective of this research is to design, fabricate, characterize, and demonstrate injection-molded, plastic microneedles. Deep Reactive Ion Etching (DRIE) will be used to fabricate silicon die inserts and an “investment casting” technique used to define the inner bore (lumen) of the needle. These silicon die inserts will be incorporated into a standard plastic injection molding machine to transfer the micron-scale features from the silicon die to the plastic microneedles. It is expected to fabricate microneedles from polycarbonate, a premium plastic.

Project end...

LPL26: Floating planar nanogap capacitor for biosensor application

Ho-Kwan Kang

The goal of this research is to develop the floating membrane nanogap capacitor for the dielectric spectroscopy exploration and the optical fluorescent observation of biomolecule.

Project end date: 08/01/03

DL16: Simulation of Micro-Fluidic Laser Heating Utilizing CFDRC

David Mun

With the recent rapid advancements in computer technology, increasingly complex and powerful simulation programs are being developed that allow engineers and scientists in a variety of disciplines to develop extremely sophisticated and detailed models which simulate phenomena that might otherwise be difficult or impossible to verify experimentally or analytically. One specific application of this new technology is in the area of computerized fluid dynamic (CFD) simulations. CFD simulations can be utilized in a myriad of situations, such as modeling jet turbines, or determining...

RTH/JDK1: A Microfabricated Electrochemical Oxygen Generator for High-Density Cell Culture Arrays

William J. Holtz
Khoa Nguyen

The goal of this project was to design, fabricate and characterize an electrochemical oxygen micro-generator suitable for use in high density miniature cell culture arrays.Arrays of miniature bioreactors were built and oxygen was supplied to them via electrochemical oxygen microgenerators.

Project end date: 08/20/03

RMW25: Microsphere Capture and Perfusion in Microchannels Using Flexural Plate Wave Structures

Justin Black

Sequential flow injection (FI) involves the temporary immobilization of functionalized microspheres as a renewable surface for (bio) chemical assays. We describe a microfabricated flow injection system that employs the ultrasonic flexural plate wave (FPW) device to acoustically capture microspheres from fluid flow. Microsphere capture is achieved by counteracting viscous drag force with radiation pressure generated from a standing acoustic field. The feasibility of acoustic trapping for FI is demonstrated with a bio-ligand assay of fluorescently labeled biotin conjugated to...