BioMEMS

We present the integration of CMOS-embedded subtractive microfluidics with single-photon avalanche diode (SPAD) fluorescence lifetime sensors, enabling independent channel addressability for parallel readout. Microfluidic channels are realized by selectively wet-etching the back-end-of-line (BEOL) metal routing above the SPAD sensors, reducing the analyte-to-active-region spacing to 7 μm while allowing for precision alignment. Simultaneous readout from two SPADs underneath two separate fluidic channels is demonstrated, establishing a pathway toward a scalable, multiplexed lab-on-CMOS...

Stroke is a leading cause of disability in the United States. Recovery from stroke is complex and ultimately limited by the brains limited ability to regenerate damaged tissue. Ideally, we would want to drive neurogenesis and angiogenesis in a stroke lesion to aid in recovery. We propose a multimodality platform for stimulating neurogenesis which simultaneously allows for electrophysiological recording of neurons in the lesion area after stroke. Our aim is to provide a paradigm for making complex substrates for nervous tissue. With various devices integrated, multiple functions can be...

Successful treatment of early stage cancer depends on the ability to resect both gross and microscopic disease, yet no method exists to identify residual cancer cells intraoperatively. This is particularly problematic in breast cancer, where microscopic residual disease can double the rate of cancer returning, from 15% to 30% over 15 years, affecting a striking 37,500 U.S. women annually. Currently, residual disease can only be identified by examining excised tumors under a microscope, visualizing tumor cells stained with specific tumor markers. This microscopic evaluation restricts...