Optogenetics techniques that have been developed over the previous decade allow cell-type specific optical stimulation of neurons in-vivo. However, it remains a challenge to perform simultaneous electrical recording while providing optical stimulation due to photoelectric artifact generated at the microelectrode recording sites. This project aims to address this challenge by developing bio- compatible microelectrode arrays with optically transparent recording sites. Current devices are optimized for performing electrocorticography (ECoG) experiments and use Indium-Tin Oxide (ITO, a transparent conductive oxide) as the electrode material. Preliminary characterization of the arrays indicate electrode impedances as low as 100kOhm and show no photoelectric artifact. These micro- ECoG (uECoG) arrays are currently being validated in a variety of novel hybrid neuroscience experiments combining optical stimulation with electrical recording, both at Berkeley and with collaborators at other universities.
Project end date: 08/14/14