Michel M. Maharbiz (Advisor)

Stroke is a leading cause of disability in the United States. Recovery from stroke is complex and ultimately limited by the brains limited ability to regenerate damaged tissue. Ideally, we would want to drive neurogenesis and angiogenesis in a stroke lesion to aid in recovery. We propose a multimodality platform for stimulating neurogenesis which simultaneously allows for electrophysiological recording of neurons in the lesion area after stroke. Our aim is to provide a paradigm for making complex substrates for nervous tissue. With various devices integrated, multiple functions can be...

This dissertation presents a millimeter-scale CMOS 64x64 single charged particle radiation detector system for cancer radiotherapy; this work is applicable to therapies including external beam radiotherapy (EBRT), targeted radionuclide therapy (TRT), and brachytherapy. We demonstrate 1 um x 1 um diode pixels capable of measuring energy deposition into a depletion region by single charged particles. These pixels can be arrayed to provide large detection areas; we demonstrate a 512 um x 512 um array. Instead of sensing the voltage drop caused by radiation, the system measures pulse...

Glial passivation and subsequent electrical insulation of implantable microelectrodes is a major bottleneck for long-term viability of neural probes. Self-deploying microelectrodes have been developed to minimize glial scarring and adverse biological effects near neural recording sites, but typically suffer from low electrode densities and deployment distance.

In this dissertation, we propose and evaluate a large displacement, self-deploying architecture using a water absorbing hydrogel to extrude a high density carbon fiber array out of a microfabricated shuttle. To enable mm-scale...