Implantable drug delivery devices that allow for remote, repeatable, and reliable drug delivery are expected to greatly improve the efficacy of medical treatments in the near future. However, few delivery systems to date have met the necessary requirements – sufficient drug storage, precision control over drug delivery, and on-demand activation – to be broadly useful. In this project, we develop an implantable drug delivery device that can be remotely controlled and provide drug on the on- demand basis for several years without replacement. We develop drug release mechanisms and nanomaterials, and incorporate all the components into a biocompatible system by establishing new fabrication methods. These devices are characterized by conducting in vitro, ex vivo, and in vivo studies.
Project end date: 08/13/14