A new era of drug discovery and development is being marched with the concept of “personalized medicine”. “Organ-on-a-chips or OCs” are one of the movements, which are to recapitulate 3-dimensional organ models in microfluidic culture platforms. By combining iPSC-derived human organ cells, individuals’ physiological response can be investigated so that the needs of animal model, inadequately representing human physiology, will be vanished in drug development in a near future. Herein,we are challenging the development of liver-, heart-, and brain-on-a-chip for the organs most frequently facing drug failure issues in the current market. Also we envision to expand the types of OCs to muscle, gut and lung, in order to ultimately represent physiological response of human on a chip. Based on personalized iPSC-derived cells, investigations on individual OCs as well as interconnection between OCs will bring meaningful inquiries in pharmacokinetics and pharmacodynamics in personalized medicine.
Project end date: 02/03/15