BPN381: SERS Signal Amplification by Optofluidic Photothermal Sample Preconcentration

Integrated microfluidic devices. Preconcentration not only improves detection sensitivity of SERS signals but also improves the reliability of the analysis by significantly increasing signal-to-noise ratio. Another reason necessitating preconcentration is the discrepancy between volumes of sample available and those consumed for analysis. The general goal is to preconcentrate a molecule based on thermophoresis in a microfluidic platform to amplify the SERS signals. Our first specific goal is to preconcentrate target molecules using and the second goal is to amplify the SERS signal of preconcentrated molecules.

Project end date: 02/20/07