Publications

Design Considerations for CMOS-Integrated Hall-effect Magnetic Bead Detectors for Biosensor Applications

Karl Skucha
Bernhard E. Boser
Ming C. Wu
Luke P. Lee
2012

This dissertation presents a design methodology for on-chip magnetic bead label detectors based on Hall-effect sensors to be used for biosensor applications. Signal errors caused by the label-binding process and other factors that place constraints on the minimum detector area are quantified and adjusted to meet assay accuracy standards. The methodology is demonstrated by designing an 8,192 element Hall sensor array implemented in a commercial 0.18 μm CMOS process with single mask post-processing. The array can quantify a one percent surface coverage of 2.8 μm beads in thirty seconds...

Thin Film Encapsulation Methods for Large Area MEMS Packaging

Armon Mahajerin
Liwei Lin
Dorian Liepmann
Tsu-Jae King Liu
2012

The past thirty years have seen rapid growth in products and technologies based on microelectromechanical systems (MEMS). However, one of the limiting factors in commercializing MEMS devices is packaging, which can be the most costly step in the manufacturing process. A MEMS package must protect the movable parts of the device while allowing it to interact with its surroundings. In addition, the miniaturization of sensors and actuators has made it possible to integrate MEMS fabrication with that of integrated circuit (IC) processing. Due to the varying requirements for different...

A Cyber-infrastructure for the Measurement and Estimation of Large-scale Hydrologic Processes

Branko Kerkez
Steven D. Glaser
Alexandre M. Bayen
Kristofer S.J. Pister
2012

Water shortages, particularly evident in the state of California, emphasize the need for a better hydrologic understanding, and improved water management techniques. The majority of the state’s water originates in the Sierra Nevada as snow, melting throughout the year to meet the needs of various stakeholders. Current measurement techniques are unable to resolve variability of the snowpack at the basin scale, and snowmelt processes are not well captured by existing hydrologic models. A system-level solution is introduced to facilitate scientific understanding and water management...

Cellular Mechanotransduction via Microfabricated Post Arrays

Adrienne Higa
Liwei Lin
Song Li
Dorian Liepmann
2012

Substrate-based biophysical cues, which interact with cells through mechanotransductive pathways, influence many biological processes and cellular behaviors. By leveraging microfabrication techniques, this work aims to build biophysical stimuli into cellular substrates through discrete microtopographic features to study cellular responses. Here, uniform and gradient arrays of circular microposts have been geometrically tuned to change the apparent rigidity of a substrate and the placement of available cellular attachment sites. Three areas of cellular interaction with these micropost...

Nanomaterial Synthesis and Integration for Sensor and Energy Applications

Heather Chiamori
Liwei Lin
Samuel S. Mao
John Clarke
Oscar D. Dubo ́n
2012

Nanostructures have unique properties that will be leveraged for next generation sensor and energy applications: large surface-to-volume ratios, increased sensitivity at lower input power levels, and higher current densities all contribute to increased functionality of nano- structure devices. The synthesis and integration of carbon-, metal-, and metal oxide-based nanostructures for sensor and energy applications are studied with the goal of nano-to-micro devices utilizing well-established micro- and nano-fabrication tools and techniques: (1) self- assembled, integrated carbon...

Microengineered Platforms For Assessing Cell-Cell Communication and Single-Cell Influences on Adult Neural Stem Cell Fate

Sisi (Siyu) Chen
Michel M. Maharbiz
David V. Schaffer
Henk Roelink
Zev Gartner
2012

The signaling environment experienced by a single cell is highly dependent on its interactions with its neighbors, which may secrete locally acting factors or act via membrane bound receptor-ligand systems. Stem cells are particularly sensitive to these signals, which act in concert to regulate self-renewal and discrete transitions into distinct fates. In the case of the adult neural stem cell, decades of in vivo and in vitro work have illustrated specific roles for different types of niche cells and some of the molecular mediators...

Electrospun Direct-write Multi-functional Nanofibers

Jiyoung Chang
Liwei Lin
Albert P. Pisano
2012

Multi-functional fibers by means of direct-write near-field electrospinning process have been developed for versatile applications on a wide variety of substrates, including flexible ones. Several mask-less lithographoy techniques have been established by using the direct- write fibers in dry etching, wet etching and lift-off processes. By selecting the proper functional materials, electrospun direct-write fibers have been demonstrated in prototype working devices, such as large array piezoelectric nanogenerators made of polymeric PVDF (Polyvinylidene fluoride) and direct-write micro...

Polymer Microfluidic Device for High-throughput Single-cell Encapsulation, Lysis, and Biological Assay

Timothy Brackbill
Albert P. Pisano
Liwei Lin
Amy Herr
2012

Single cell analysis is the present and future of biological research. It’s becoming clear that sub-populations of cells within a larger group can often be the culprit for diseases or malfunctions. In this work we aim to provide a tool that allows biological researchers to better analyze single cells within cell populations by removing the barrier to observing analytes contained within the cell’s membrane. By providing physical access to the intracellular compounds in a single cell, we can analyze individual cells for levels of analytes that were previously only available through...

MEMS Materials and Temperature Sensors for Down Hole Geothermal System Monitoring

Sarah Wodin-Schwartz
Albert P. Pisano
Liwei Lin
2013

The advancement of renewable energy technologies is critical due to the unsustainable nature of currently used energy sources and the need to meet increasing energy demands. A broad and diverse energy plan is important for long term energy independence and stability. Geothermal energy sources including hydrothermal systems and enhanced geothermal systems (EGS) should play a key role in this energy plan. Geothermal energy is the most reliable, currently developed, schedulable alternative energy source. It is estimated that improvements in these systems have the potential to...

Nanomaterials Processing Toward Large-scale Flexible/Stretchable Electronics

Toshitake Takahashi
Ali Javey
Tsu-Jae King Liu
Liwei Lin
2013

In recent years, there has been tremendous progress in large-scale mechanically flexible electronics, where electrical components are fabricated on non-crystalline substrates such as plastics and glass. These devices are currently serving as the basis for various applications such as flat-panel displays, smart cards, and wearable electronics.

In this thesis, a promising approach using chemically synthesized nanomaterials is explored to overcome various obstacles current technology faces in this field. Here, we use chemically synthesized semiconducting nanowires (...