Luke P. Lee (Advisor)

CMOS Magnetic Particle Flow Cytometer

Pramod Murali
Bernhard E. Boser
Ali M. Niknejad
Luke P. Lee

Neutrophils, a class of white blood cells, are our body’s first line of defense against invading pathogens. When the number of neutrophils in blood drops to 200cells/$\mu$L, it leads to a critical clinical condition called neutropenia. Currently, optical flow cytometry is the most common and powerful technique used to diagnose neutropenia, but the centralized nature of the test, time-consuming sample preparation and high cost prevent real-time modification of treatment regimens.

In this thesis, we propose an approach of using magnetic labels to tag and detect cells that allows us...

Charlie (Erh-Chia) Yeh

Professor Luke P. Lee (Advisor)
Ph.D. 2015

Minsun Song

Professor Luke P. Lee (Advisor)
Ph.D. 2019

LPL26: Floating planar nanogap capacitor for biosensor application

Ho-Kwan Kang

The goal of this research is to develop the floating membrane nanogap capacitor for the dielectric spectroscopy exploration and the optical fluorescent observation of biomolecule.

Project end date: 08/01/03

LPL10: Disposable Integrated Optical MEMS and Microfluidic Channels for High Resolution Biochip Array

Jeonggi Seo

The goal of this project is to integrate and qualify micro-optical systems with microfludic channels in order to advance the functions of micro total analytical systems (mTAS). The disposable self-aligned integrated microfluidic optical systems (SiMOS) with planar optical systems have the potential to open a new period to mTAS because of low-cost, simple fabrication steps and aberration-free optical systems. We believe the SiMOS provide a new paradigm of integrating optical systems to mTAS.

Project end date: 08/22/03

LPL30: 3D Alignment of Collagen Fibrils in Microchannels

Philip Lee
Rob Lin

Artificial 3D architectures of collagen fibers using microfabricated polymer structures has exciting medical applications. Aligned collagen matrices more closely resemble tissues found in nature. Collagen alignment may prove beneficial for tissue regeneration, show enhanced mechanical properties, and serve as a biomimetic material. Moreover, the basic biophysical characterizations of aligned collagen fibrils will provide an insight for the mechanism of electrical signal transductions and electromechanical actuations of our tissues.

Project end date: 08/27/03

DL12: Fluid Dynamics in Nanoscale Environments

Troy Lionberger
Boris Stoeber

This project focuses on the analysis of fluid behavior in sub-micron scale environments using microfabricated nanochannels with the intent of investigating applications such as the development of ultra-sensitive detection systems. The small scale in which the experiments will be conducted allows for the generation of extremely high levels of shear in the fluid. In addition, the fluid is expected to behave differently in the nanochannels than at the macroscale due to the increasingly significant contribution of intermolecular forces and because double layers formed along the sidewalls...

LPL13: Vertically-Integrated Micro Confocal Imaging Array (VIµ-CIA)

Sunghoon Kwon

The goal of this project is development of MEMS laser scanning confocal microscopes for multiplexed Lab-On-A-Chip applications. The hybrid integration of microfabricated microlens scanner and confocal pinhole, laser diodes, and photodiode allows to create handheld sized autonomous confocal excitation and detection microsystem. Without use of bulky external microscopes, we have successfully demonstrated laser induced fluorescent excitation and detection from multiple of microfluidic channels and reflectance image reconstruction using the developed system.

Project end...

LPL22: Electronic Properties of DNA for Bioelectronics

Yang-Kyu Choi

Conduction mechanism in DNAs has been investigated for tangled structures. Thus, the conduction mechanism is still ambiguous because of complicated conducting paths. In this work, DNA will be stretched by using sub-10nm gap electrodes, which are defined by novel spacer lithography. Stretched DNA chain can be confined at the nano-gap electrodes made of poly-silicon across and along the gaps. Then, conductance mechanism will be thoroughly investigated along phosphate chain and hydrogen bond. Previous works showed that A/T and G/C were n-type and p-type semiconductors, respectively. If...