Dorian Liepmann (Advisor)

Research Advised by Professor Dorian Liepmann

DL13: Multidirectional Force and Torque Sensor for Insect Flight Research

Mansoor Nasir

In order to understand the unsteady aerodynamics of insect flight, a sensor has been fabricated that measures the small multidirectional forces generated by fruit flies during tethered flight while simultaneously supporting it inside a LED flight simulator arena. This sensor will provide quantitative data that will help to better understand sensorimotor mechanisms of flight control in flying insects.

Project end date: 01/29/08

BPN414: Disposable Microsyringe for Single Dose Vaccine Delivery

Zachary Lee

With the development of transdermal drug delivery methods there is a growing potential for creating safer and more efficient means of vaccine delivery and improving access for children in remote areas of developing countries. Problems with conventional needle delivery in areas with limited supplies include the risk of blood borne pathogen transmission through accidental needle sticks, wastage and contamination during the reconstitution process, storage and cold chain maintenance. Microneedle based drug delivery systems consisting of an array of pointed, out-of-plane microneedles have...

BPN321: Realization of 3D Isotropic Negative-Index-Material (NIM) using Microfabrication Technology

Logeeswaran Veerayah Jayaraman

In this project, we propose to realize for the first time, a three dimensional (3D), homogeneous, isotropic Negative-Index-Material(3D-NIM) implementation which allows left-handed behavior for any direction of propagation and any polarization of the electromagnetic wave using micromachining, microfabrication and microassembly (MEMS) techniques with the aim of establishing a basis platform for massively parallel manufacturing of NIM. Besides having a passive metamaterial, integration of modulation mechanisms with lower metal losses will also be explored. This approach will provide a...

BPN482: Micro-Digital Particle Image Velocimetry Using LED Illumination

Bakhshinder Nijjar
Varun Boriah

Micron-resolution particle image velocimetry systems that measure flow-fields in micron-scale fluid devices have been used for almost 10 years at BSAC and other institutions, but are plagued with high capital costs and their cumbersome operating requirements. This work envisions creating a µ DPIV system that is considerably smaller, cheaper, easier to use and less hazardous. The proposed µ DPIV system achieves these goals through replacing the dual cavity Nd:YAG laser with a high power LED. In addition to the above benefits, a LED based µ DPIV system has advantages of adaptability...

BPN486: Enhancing Shear-Mediated Arteriogenesis in Cerebral Vessels

Tyson N. Kim

Occlusive arterial disease, including stroke and heart attack, is the leading cause of mortality and morbidity in Americans. There is significant interest in developing molecular therapy to stimulate blood vessel growth and return blood flow to dying tissue. Our research may elucidate an important biological mechanism that controls artery growth, helping in the development of molecular treatments for occlusive arterial disease.

Project end date: 08/18/11

BPN326: Development of a Microstimulator Implant for Neuromuscular Disease

Maral Gharib

Facial nerve dysfunction is a common problem affecting both genders, all races, and all ages and is caused by numerous medical problems, including stroke. In particular, the inability to blink causes serious long term problems both physically and psychologically. Electrical stimulation of a blink does not work because the current needed to induce a blink also causes intense pain. The long-range objective of our research is to develop an artificial synapse chip system that can be used in a novel therapeutic strategy for denervated muscles by mimicing the natural stimulation that...

BPN620: Surface Topology Optimization for Directing Fluid Flow

Sho Takatori
Kathryn Fink

Sample capture transport of biological fluids, like blood flow in diabetes glucose monitors, often requires microfluidic actuation. Current commercial methods used in diabetes glucose monitors usually involve porous materials or hydrogels, but these strategies are limited in fluid control. Surface wettability gradient actuation is an approach widely used in various other microfluidic or lab-on-a-chip systems. Here we design and fabricate a droplet-actuation device that relies purely on capillary pressure gradients induced by surface topologies. We discuss the theoretical capabilities...

BPN695: Hydrodynamics of Marine Larval Locomotion

Rachel Pepper

We want to understand how microscopic swimmers navigate in complicated flow fields where the ambient fluid flow speed is much greater than their swimming speed. Up to now, the motility of these organisms, ranging from bacteria to small planktonic animals, has been studied in still water. While this is an important first step, it is essential to connect the motion in still fluid to the locomotion of organisms in their more complicated natural environments. In flowing water, these organisms are carried by the flow around them and can make only minor adjustments to their trajectory by...

BPN622: Design of an Ex Vivo Prototype of a Bioartificial Kidney

Peter Soler

The goal of this project is to design, fabricate, and study a bioartificial kidney. The motivation behind the project is to further the development toward an implantable bioartificial human kidney that will improve quality of life and reduce cost for end stage renal disease (ESRD) patients. My proposed device contains two units: i) a hemofilter based upon nanoporous silicon membranes, and ii) a bioreactor composed of kidney proximal tubule (PT) cells. The focus of my study is to develop a device design that is optimized for adequate mass transport so as to mimic natural kidney...

BPN621: Microfluidic Separation of Blood

Kathryn Fink
Karthik Prasad

The goal of this research is to characterize and optimize a continuous-flow, blood fractionation platform using particle image velocimetry to analyze the critical operating parameters. The microfluidic system will separate from a blood sample a platelet-enriched plasma containing pathogens and pathogenic biomarkers. It will also provide a stream of concentrated blood cells including pathogenic plasmodial cells.

Project end date: 02/02/15