Jun-Chau Chien (Advisor)

Implementing dual-resonance class-F oscillators with transformer feedback beyond 60 GHz poses significant challenges due to the limited third-harmonic tank impedance when using small coils with low coupling factors. To address these limitations and leverage the phase noise advantages of class-F operation, this letter introduces a standing-wave oscillator (SWO) topology featuring an on-chip multiband transmission-line (t-line) resonator loaded with harmonically tuned open stubs. The proposed design enhances third-harmonic resonance while facilitating precise alignment of the...

Electrochemical aptamer-based (E-AB) sensors undergo structure-switching upon target binding, making them well-suited for in vivo continuous monitoring of biomolecules with high sensitivity and selectivity. Although square-wave voltammetry (SWV) is the most widely used analytical technique for probing the states of E-AB sensors, precise signal extraction from SWVs acquired during in vivo measurements remains challenging. The difficulty arises due to additive electronic and chemical noise, as well as varying background currents caused by factors such as the reduction of dissolved oxygen,...

Point-of-care (POC) diagnostics can revolutionize current medicine by enabling rapid, at-home molecular testing for early disease detection and treatment monitoring. Though several mainstream POC technologies exist, such as paper-based lateral flow assays (LFAs) and microfluidic cartridges, they either lack quantification capability or require a dedicated reader for electrical readout. Miniaturization enabled by high-performance CMOS integrated circuits (ICs) has been proposed to address these limitations, but complex CMOS/microfluidics packaging due to the need for electrical connections...