NanoPlasmonics, Microphotonics & Imaging

Current quantum processor units (QPUs) have achieved over 1,000 qubits (e.g., IBM's Condor processor). However, scaling quantum platforms toward 1 million qubits demands breakthroughs in quantum hardware, connectivity, error correction, and system architecture. To address the scalability of quantum interconnects, Cryo-CMOS control and readout circuits have demonstrated efficacy in reducing wiring complexity, latency, and thermal loads. However, the CMOS circuits limit the active heat load to 1–2 mW/qubit, imposing a limit of approximately 1,000 qubits in state-of-the-art dilution...

Implantable sensors capable of real-time monitoring of complex cellular dynamics can provide critical information for understanding disease progression and treatment response, leading to more personalized medicine. An impactful application is in cancer immunotherapy which produces durable responses but suffers from low response rates (<50%). Multicolor fluorescence microscopy is a critical tool for the study of multi-cell type dynamics but limited optical penetration depth (<5 mm for 400-900nm) and bulky optics constrain its use in vivo. Therefore, wireless, miniaturized...

In curative-intent cancer surgery, intraoperative fluorescence imaging of both diseased and healthy tissue can help to ensure the successful removal of all gross and microscopic diseases with minimal damage to neighboring critical structures, such as nerves. Current fluorescence-guided surgery (FGS) systems, however, rely on bulky and rigid optics that incur performance-limiting trade-offs between sensitivity and maneuverability. Moreover, many FGS systems are incapable of multiplexed imaging. As a result, clinical FGS is currently limited to millimeter-scale detection of a single...

Successful treatment of cancer requires targeted and individualized treatment, and subsequently an assessment of the state of the tumor being examined, both gross and microscopic, however oncologists have no method of identifying microscopic tumor in the patient. This results in tumor cells being left behind in patients undergoing surgery. Currently, the only way to determine the presence of any microscopic residual is to examine the excised tumor, stained with a proper marker, under a microscope, which only adds to the complexity and length of the surgery and treatment. The two current...