Luke P. Lee (Advisor)

LPL29: Nanoprobes for Monitoring Sub-cellular Response to Localized Surface Interactions

Philip J. Lee
2004

We are developing devices with nanoscale features for the analysis of real time cell response to localized stimulation. This enables the tracking of signaling molecules to/away from the site of interaction. Monitoring of cell behavior will be useful for biosensors, tissue engineering, and single cell manipulation.

Project end date: 02/12/04

LPL27: Biomimetic Imager as Omnidirectional Sensor (BIOS)

Paul Hung
Gang Logan Liu
2004

The ultimate goal of this project is to demonstrate an ultra-wide field-of-view (FOV) optical sensing system capable of accurately detecting and imaging targets at various distance and direction.

Project end date: 08/18/04

LPL25: Tunable Microdoublet Lens Array

Ki-Hun Jeong
2004

We report a novel tunable microdoublet lens capable of creating dual modes of biconvex or meniscus tunable lens. The microlens consists of a tunable liquid-filled lens and a solid negative lens and it can be tuned either by changing the shape of the liquid-filled lens into bi-convex or meniscus or by changing a filling media with different refractive index. The microfabrication is based on soft lithography and photopolymer microdispensing technologies. The microlens can provide a solution for minimizing optical aberrations as well as maximizing the tunability of focal length or field...

LPL11: Integrated Polymer Actuators in Microfluidic Systems

Nikolas Chronis
2004

To develop polymer-based actuators that can operate inside microfluidic systems and investigate their capabilities and limitations.

Project end date: 08/18/04

LPL20: A new pressure tranduction mechanism using elastomer micromolding

Cristian Ionescu-Zanetti
2004

Local on-chip pressure sensing is an important application of micro-electro-mechanical devices. Traditionaly, sensing has been done based on either piezoelectric material properties or capacitance measurements across a micromachined cavity.

Project end date: 08/18/04

LPL18: Nanopillar Substrate for Surface-Enhanced Raman Spectroscopy

Gang L. Liu
2004

Nanopillar structures are fabricated in batch process with controllable geometry and pattern. After metallization, nanopillars will be used as Raman signal enhancing substrate. Through the surface modification of substrate with differently patterned nanopillars and the incorporation with micro/nano fluidics and MEMS scanning optics, high-sensitivity multiplexed biomolecule recognitions by SERS can be realized on a chip.

Project end date: 08/18/04

LPL28: Microfluidic-Based Two-Dimensional Protein Chip

Paul Hung
2004

Demonstration of a microfluidic device at a size of 3”x3” for two-dimensional separation of proteins. The goal is to provide a better tool for proteomics research with faster turnaround time, less reagent consumption, less bio-waste production, as well as better resolution to distinguish similar biomolecules.

Project end date: 08/30/04

LPL21: Biomimetic Microfabricated Compound Eyes

Ki-Hun Jeong
Jaeyoun Kim
2005

In this project, we will design, fabricate, and characterize compact, integrated optical image sensors with field-of-view (FOV) angles ranging from 0 to >120. In order to accomplish compactness, manufacturability, and wide FOV simultaneously, we will adopt bio-mimetic approaches in which miniature biological imaging structures exhibiting the required features are replicated based on our technical expertise in polymer micro-machining and polymer micro-optics techniques. For further miniaturization of the imaging systems, we will develop fabrication techniques for self-writing of a...

LPL33: Time Division Multiplexed Microfluidic Lateral Patch Clamp Array

Mike Mueller
Michelle Khine
Cristian Ionescu-Zanetti
Niraj Patel
2005

Our goal is to apply newly emerging technology in MEMS and microfluidics to create a high-throughput electrophysiology platform for characterizing ion channels in drug discovery and drug development. We plan to replace the micropipette of the original patch clamp design with Ag/AgCl electrodes, and form arrays of electrodes to create a high-throughput patch clamp system on a chip. The device should be high-throughput, to increase the amount of data able to be collected per unit time. Furthermore, the device should be largely automated, in order to reduce or eliminate the manual labor...

BPN310: Integrated Microfluidic SERS Devices

Beomseok Kim
Jeonggi Seo
2005

Raman is a label-free analytical method, which offers tremendous advantages for biomolecular detection. Surface-enhanced Raman scattering (SERS) technique can overcome the low cross-sectional problems inherent in Raman spectroscopy. SERS has been observed for a very large number of molecules adsorbed on the surface of Au or Ag in a variety of morphologies and physical environments. With these environments, its detection limit can reach up to 6-10 orders of magnitude over conventional Raman spectroscopy. We know nanoparticle sizes (15-200 nm) and interparticle spaces (0-10 nm) are...