BioMEMS

Research that includes:

  • Immunosensors
  • Single Cell Analysis
  • Cell Manipulation and Probing
  • SERS BioImaging
  • Micro Total Analysis Systems uTAS
  • DNA Transformations
  • Cell Cryropreservation
  • Optoelectronic Transport & Tweezers

BPN729: Development of Microfluidic Devices with Embedded Microelectrodes Using Electrodeposition and Hot Embossing

Marc Chooljian
2019

The use of microfluidic devices has experienced a tremendous increase over the last years, which is especially valuable for healthcare applications. In this context, plastic materials are increasingly relevant, especially for large scale fabrication and commercialization. However, plastics are still not widely used at the research level due to the lack of available inexpensive industrial-like fabrication equipment. In this work, we describe a rapid and highly cost-effective approach for fabricating plastic microfluidic...

BPN870: Hot Embossed Thermoplastic Bubble-Actuated Micropump

Marc Chooljian
Ani Siyahian
2019

Advances in technology have allowed for the development of health diagnostics microdevices, but implementation of microdevices for drug delivery is relatively new. Continuous drug delivery often requires large and complex pumps, making development of micropumps desirable. Similarly, commonly used materials such as silicon are too expensive for mass production of disposable devices, and polydimethylsiloxane (PDMS) is not compatible with some pharmaceutical drugs due to partitioning effects in the PDMS matrix. Thermoplastic...

BPN442: MEMS Poly/Nano: Multifunctional Nanowire Sensor for Physiological pH and Oxygen Sensing

Sun Choi
2010

The long range goal of this project is to develop a multifunctional silicon nanowire array sensor in microfluidic system for real-time detection of physiological parameters such as pH level and oxygen concentration dissolved in the aqueous environment. The sensing targets include the medium of cultured mammalian cells or microbial species such as bacteria. During certain types of metabolism processes of these biological species, extracellular environment will experience changes of pH levels and oxygen concentration. Our goal is to design nanowire array sensor which can be integrated...

BPN666: Dynamic Fetal Airway Occlusion for Treatment of Congenital Pulmonary Hypoplasia

Mozziyar Etemadi
2012

Congenital lung hypoplasia--lungs that are small and underdeveloped at birth--claims the lives of over 4000 children annually in the United States. This is close to a sixth of all infant deaths. Causes of pulmonary hypoplasia share one commonality: they all interrupt normal chest anatomy, limiting the space that the lungs have to grow. For the last three decades, clinicians have been giving the lungs a way to "push back" and expand this limited space. Fetal lungs are constantly secreting fluid, and by "trapping" this fluid in the lungs using in utero therapies, clinicians have...