BSAC Technology Seminar: Applications of Quantum Electrochemical Spectroscopy to Disease Diagnosis and Drug Development

BSAC Technology Seminar Committee

Jonathan Candelaria
Dalene Schwartz Corey
February 6, 2024

Tuesday, 06 February 2024 at Noon | 490 Cory Hall

Watch the seminar recording here

Roger T. Howe, Ph.D. 

Professor, Stanford University
Host: Jonathan Candelaria


Spectroscopic techniques generate rich datasets, which historically have been challenging to analyze. The tremendous expansion of machine learning has made spectroscopy more feasible; however, there are only a handful of such techniques, such as mass spec, Raman spectroscopy. Research at Stanford [1] demonstrated a broad-spectrum, quantum electrochemical spectroscopy (QES) technique, which is being commercialized by Probius, Inc. After a review of the underlying chemical physics of the nanoscale transducer and its fabrication, I will discuss several early applications of QES, including more efficient insights for accelerating the development of drug candidates [2] and predicting the course of tuberculosis infections [3].

As an addendum to the technical talk, I will provide some perspectives on academia as a career path based on teaching for nearly 40 years in four research universities.

  1. S. Fischer, et al, “Low-noise integrated potentiostat for affinity-free protein detection with 12 nV/rt-Hz at 30 Hz and 1.8 pArms resolution,” IEEE Solid-State Circuits Letters, 2, 41-44 (2019).

  2. C. Gupta, et al, “Quantum Electrochemical Spectroscopy (QES): A novel AI- driven spectroscopic approach to simplify bioanalytical development in the pharmaceutical industry,” AAPS PharmSci 360, Orlando, Florida, Oct. 22-25, 2023, T1430-06-37.

  3. C. Gupta, et al, “Quantum Electrochemical Spectroscopy (QES): A novel approach for enhanced detection and evaluation of drug-induced liver injury (DILI), AAPS PharmSci 360, Orlando, Florida, Oct. 22-25, 2023, M1530-10-63.

  4. C. Gupta, et al, “Using the digital phenotype of disease in human plasma for simplified and accurate prediction of tuberculosis and HIV infection, “Assoc. for Mol. Pathology (AMP) Annual Meeting, Phoenix, Ariz., Nov. 1-5, 2022.


Roger T. Howe is the William E. Ayer Professor, Emeritus in the Dept. of Electrical Engineering at Stanford University. He received a B.S. in physics from Harvey Mudd College in 1979 and an M.S. and Ph.D. in electrical engineering from the University of California, Berkeley in 1981 and 1984. After faculty positions at CMU and MIT from 1984 – 1987, he returned to Berkeley for 18 years, where he was a Professor and a BSAC Director. His research group at Stanford has focused on nanoscale system design and fabrication for a variety of applications. He was the Faculty Director of the Stanford Nanofabrication Facility from 2009 – 2017 was Director of the NSF’s National Nanotechnology Infrastructure Network (NNIN) from 2011 – 2015. In 2016, he co-founded Probius, Inc. to commercialize research in his group on broad-spectrum biomolecular sensing.


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