BSAC Seminar: Toward Closing the Loop: Circuits and Systems for Real-Time Neurochemical Sensing and Activity-Dependent Intracortical Microstimulation

April 26, 2011

Prof. Pedram Mohseni

Department of Electrical Engineering and Computer Sciences, Case Western Reserve University
April 26, 2011 | 12:00 to 01:00 | 540 Cory Hall, DOP Center Conference Room
Host: Michel Maharbiz

To date, brain-machine interfaces (BMIs) have sought to interface the brain with the external world using intrinsic neuronal signals as input commands for controlling external devices, or device-generated electrical signals to mimic sensory inputs to the nervous system. A new generation of neuroprostheses is now emerging that aims to combine neural recording, signal processing, and microstimulation functionalities for closed-loop operation. These devices might use information extracted from brain chemical and electrical neural activity to trigger microstimulation or modulate stimulus parameters in real time, potentially enhancing the clinical efficacy of neuromodulation in alleviating pathologic symptoms or restoring lost sensory and motor functions in the disabled. This seminar will first present novel integrated recording systems that can concurrently sense neurochemical signals and neural action potentials in the brain. Prototype devices fabricated in 0.5-um CMOS have successfully recorded chemically-resolved levels of dopamine evoked by electrical stimulation as well as amphetamine administration in anesthetized and ambulatory rats with fast-scan cyclic voltammetry (FSCV) at a carbon-fiber microelectrode (CFM). The presentation will then focus on a miniaturized system for activity-dependent intracortical microstimulation as a novel approach for potentially orchestrating new long-range connectivity patterns in the cerebral cortex after brain injury. The neurophysiological rationale behind this work as well as our measurement results from a prototype device fabricated in 0.35-um CMOS will be presented in anesthetized and ambulatory rats. This work has the potential to remarkably advance the neurorehabilitation field at the level of functional neurons and networks.

Interested in nominating someone to speak at the BSAC Technology Seminar? We welcome you to submit a speaker nomination here(link is external)

Watch this BSAC Technology Seminar

BSAC Technology Seminar Series

BSAC Technology Seminar Series
Hosted by Berkeley Sensor & Actuator Center
bsac.berkeley.edu

Upcoming Events

BSAC Technology Seminar Committee

Jonathan Candelaria
Dalene Schwartz Corey