Prof. Hiroyuki Fujita
Director, Center for International Research on Micronano Mechatronics (CIRMM), University of Tokyo
March 3, 2015 | 12:30 to 01:30 | 540 Cory Hall
Host: Liwei Lin
MEMS fabrication and microactuators emerged in the late 1980’s. Today, these devices are applied to commercial products and to scientific tools for nano and bio technologies. This enables precise measurement of the mechanical, electrical, and chemical properties of nano/bio objects with simultaneous observation by optical or electron microscopy. Prof. Hiroyuki Fujita will discuss how MEMS devices can provide single molecular-level assay capabilities associated with visualization of the motion of motor proteins:
(1) Micromachined fL-chambers and magnetic tweezers allowed the single molecular-level enzymology of F1-ATPase, a rotational biomolecular motor. Millions of arrays of such chambers allow “digital ELISA” offering orders of magnitude improvement in sensitivity compared to conventional methods,
(2) Reconstructed linear biomolecular motors on a glass plate by pick-and-place assembly using MEMS tweezers. The reconstructed biomolecular motor system was utilized for direct sorting and transportation of specific sample molecules, as well as for detecting the interaction between the tau protein (which is a promising biomarker for Alzheimer’s disease) and microtubules.
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