BSAC Seminar: Robotizing Functional Nanoentities for Single-Cell Drug Delivery, Bioanalysis and Tunable Biochemical Release

April 29, 2014

Prof. Donglei (Emma) Fan

Department of Mechanical Engineering, University of Texas at Austin
Materials Science and Engineering Program, Nanomaterial Innovation Lab
April 29, 2014 | 12:30 to 01:30 | 540 Cory Hall
Host: Luke Lee

In this talk, I will discuss innovative concepts and approaches for robotizing functional nanoentities into highly controllable nanomotors for single-cell drug delivery, bioanalysis and tunable biochemical release. Arrays of designed nanoparticles can be precisely transported along arbitrary trajectories, assembled and actuated as various nanoelectromechanical (NEMS) devices (or nanomotors) by the electric tweezers - our recent invention. The nanomotors can deliver biosignals to a single live cell amidst many for signal transduction. Functionalized with plasmonics, they can analyze the composition of the membrane of a live cell. Assembled into rotary NEMS, they can precisely tune the release rate of biochemicals by the mechanical rotation. Here, the rotary nanomotors, with nanowires and nanomagnets as building blocks, are the smallest (all dimensions <1μm), fastest (18,000 rpm), and most durable rotary NEMS (operate continuously for 15 hours over 240,000 cycles). The innovations reported in this research, from concept, design, actuation, to application could be inspiring for NEMS, nanomedicine, microfluidics, and lab-on-a-chip architectures. 

www.me.utexas.edu/~dfanwww.me.utexas.edu/directory/faculty/fan/donglei/221

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Jonathan Candelaria
Dalene Schwartz Corey