Dr. Yi-Kuen Lee
Center for Bioengineering & Biomedical Device, Hong Kong University of Science and Technology
February 21, 2012 | 12:00 to 01:00 | 540 Cory Hall, DOP Center Conference Room
Host: Liwei Lin
Mixing is one of the most important microfluidic processes in biochemistry analysis, fine chemical production, polymer chain reaction (PCR), genotyping, sequencing and synthesis of nucleic acids. In the past decade, a large number of different types of new micro mixers have been reported for various applications. Recently, micro chaotic mixers have been used for microfluidic chips to capture Circulating Tumor Cells (CTCs) of which the enumeration can be a new cancer diagnostics solution. However, detection and characterization of CTCs has been technically challenging due to the extremely low abundance (0.7-176 cells per mL) of CTCs among a high number (10⁹ cells per mL) of hematologic cells in the blood. I will focus on design of a micro chaotic mixer with integrated antibody-coated Si nanostructured CTC chip, especially the optimization of the device to increase CTC capture efficiency. The estimated minimum cycle of the micro chaotic mixer is consistent with the experimental results using an integrated CTC chip and MCF-7 breast cancer cells. The fabricated CTC chips have been used in the clinical experiments at UCLA Medical Center.
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