Dr. F. Nazly Pirmoradi
Department of Mechanical Engineering, UC Berkeley
BSAC Postdoctoral Researcher
October 30, 2012 | 12:00 to 12:30 | 540 Cory Hall, DOP Center Conference Room
Host: Liwei Lin
The effectiveness of drug therapy is dependent on the availability of therapeutic concentrations of drug at the disease site. Controlled and localized drug delivery systems provide temporal and spatial control of drug release and offer significant advantages over immediate release, conventional delivery systems. In this talk, Dr. Pirmoradi reports on the development of an implantable MEMS drug delivery device capable of on-demand release of defined quantities of an antiproliferative drug, docetaxel (DTX). Remotely operated delivery via the MEMS device has achieved controlled release of DTX with a dosage suitable for the treatment of diabetic retinopathy (DR) over 17 months. The investigations on the biological activity of released DTX confirmed the drug antiproliferative effect, two months after it was packaged in the MEMS device. This battery-less device has been successfully demonstrated to conduct controlled, ex vivo drug transport to human eye tissue, as such, DTX can penetrate the first two barrier layers, sclera and choroid, to reach retina for treatment of DR.
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