Efthymios Papageorgiou
Department of Electrical Engineering and Computer Science, UC Berkeley
May 9, 2019 | 03:30 to 04:30 | 490 Cory Hall
Host: Bernhard Boser, Mekhail Anwar
Dissertation Presentation
There is a persistent need for an intraoperative device that is capable of detecting microscopic residual disease (MRD), small clusters of hundreds to thousands of cancer cells left behind after the gross tumor is removed during a surgical resection.
This talk presents an image sensor incorporating angle-selective gratings for resolution enhancement in contact imaging applications. Optical structures designed in the CMOS metal layers above each photodiode form the angle-selective gratings that limit the sensor angle of view to 18 degrees, rejecting background light and deblurring the image. The sensor is designed specifically for the intraoperative detection of MRD. A custom 15um thickness amorphous silicon optical wavelength filter is used alongside the image sensor in order to perform fluorescence imaging. The filter is compatible with several clinically tested fluorophores, such as IR700DX.
We demonstrate imaging and detection of foci containing less than 200 cancer cells labeled with fluorescent biomarkers in 50ms. We also demonstrate the detection of microscopic cancer using human tissue and residual tumor in mice models. The absence of large optical elements enables extreme miniaturization, allowing manipulation within a small, morphologically complex, tumor cavity.
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