Efthymois Phillip Papageorgiou
Department of Electrical Engineering and Computer Sciences, UC Berkeley
BSAC Graduate Researcher, Bernhard Boser Group
November 14, 2017 | 12:00 to 01:00 | 490 Cory Hall
Host: Michael Cable
Modern cancer treatment faces the pervasive challenge of identifying microscopic cancer foci in vivo, but no imaging device exists with the ability to identify these cells intraoperatively, where they can be removed. The removal of these foci is known to more than halve cancer recurrence rates across a wide variety of cancers, including breast and prostate. We present a novel contact fluorescence imaging system based on an angle-selective CMOS image sensor that identifies foci of less than 200 cancer cells in real-time while maintaining a small form factor. Recognizing that focusing optics traditionally used in fluorescence imagers present a barrier to miniaturization, we integrate stacked CMOS metal layers above each photodiode to form angle-selective gratings, rejecting background light and deblurring the image. The sensor's miniature size enables manipulation within a small, morphologically complex tumor cavity, that could not be adequately imaged with currently available technologies.
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