Ming C. Wu (Advisor)

Research Advised by Professor Ming C. Wu

Integrated Nanoplasmonic Optical Microfluidics for Label-free Bioassays

Yir-Shyuan Wu
Luke P. Lee
Ming C. Wu
Steve Conolly
2009

Current cellular assays are limited to multi-well based cell culture samples, and the existing cellular protein detection methods are restricted to labeling the targeting molecules with fluorescent dyes or other reporters. Microfluidic cell culture technology can provide precise and physiologically relevant microenvironment control to improve the quality of cell based assays. Nanoplasmonic optical probes enable the label-free detection of cellular protein with high temporal and spatial resolution. The goal of this dissertation is to develop and integrate real-time label-free...

Biologically-inspired Microfluidic Platforms and Aptamer-based Nanobiosensors

Hansang Cho
Luke P. Lee
Dorian Liepmann
Ming C. Wu
John Kurhanewicz
2010

Recent advances in micro/nano- technologies have shown high potentials in the field of quantitative biology, biomedical science, and analytical chemistry. However, micro/nano fluidics still requires multi-layered structures, complex plumbing/tubing, and external equipments for large-scale applications and nanotechnology-based sensors demand high cost. Interestingly, nature has much simpler and more effective solutions. The goal of this dissertation is to develop novel microfluidic platforms and nanobiosensors inspired by biological systems.

In this dissertation, I...

Design Considerations for CMOS-Integrated Hall-effect Magnetic Bead Detectors for Biosensor Applications

Karl Skucha
Bernhard E. Boser
Ming C. Wu
Luke P. Lee
2012

This dissertation presents a design methodology for on-chip magnetic bead label detectors based on Hall-effect sensors to be used for biosensor applications. Signal errors caused by the label-binding process and other factors that place constraints on the minimum detector area are quantified and adjusted to meet assay accuracy standards. The methodology is demonstrated by designing an 8,192 element Hall sensor array implemented in a commercial 0.18 μm CMOS process with single mask post-processing. The array can quantify a one percent surface coverage of 2.8 μm beads in thirty seconds...

Integrated Microfluidic Molecular Diagnostics for Point-of-Care

Charlie (Erh-Chia) Yeh
Luke P. Lee
Ming C. Wu
2015

Ideal point-of-care medical diagnostic devices are low cost assays capable of performing quantitative on-site rapid testing with high sensitivity and minimal manual steps.

Current mainstream assays have several key limitations. Take, for instance, the common lateral flow assay—e.g. the pregnancy dipstick test. Such assays produce rapid results at low cost; however, they are mostly qualitative tests yielding only positive/negative results rather than quantitative figures. Other standard immunosorbant assays such as ELISA yield quantitative results but require...

Integrated Molecular Diagnostic Platform

Byungrae Cho
Luke P. Lee
Ming C. Wu
Randall J. Lee
2017

Infectious and non-communicable diseases impose a global burden of health on both developing and developed countries despite technological advancements in medicine and healthcare. In this perspective, point-of-care testing (POCT) has been paid attention as an area with enormous potential to solve this problem. Point-of- care molecular diagnostic enables to provide diagnoses from clinical samples to clinicians without wasting time such as sample transporting or sample preprocessing. However, most of nucleic acid diagnostics still are performed in central health facilities because they...

Philip L. Jacobson

Graduate Student Researcher
Electrical Engineering and Computer Sciences
Professor Ming C. Wu (Advisor)
Ph.D. 2024 (Anticipated)

Philip is currently a second year Ph.D. student working in Prof Ming Wu's group on novel architectures for Machine Learning using Integrated Photonics.

Pick and Place Silicon on Insulator Microassembly

Matthew Last
Kristofer S.J. Pister
Ming C. Wu
Liwei Lin
2005
Deep reactive ion etching into Silicon on Insulator (SOI) wafers is a popular method of fabricating high-performance MEMS devices. These include electrostatic and thermal actuators, flexures that guide very precise motion, and ultra-flat and smooth reflectors to make micro-mirrors. An important limitation of SOI-based MEMS is that it is not easy to achieve a large range of out-of-plane motion without a complex fabrication process. This is because of the difficulty in...

Chao-Hsi Josh Chi

Alumni
Electrical Engineering and Computer Sciences
Professor Ming C. Wu (Advisor)
Ph.D. 2006

Tunable Optical Microresonators with Micro-Electro-Mechanical-System (MEMS) Integration

Jin Yao
Ming C. Wu
2007

Optical microresonators are key enabling elements for many photonic integrated circuits (PICs) areas. Their applications include modulators, optical filters, optical delay lines, nonlinear optical devices, and optical sensors. In previous demonstrations, the coupling of the resonator and its input/output is generally fixed, or tuned using non- integrated alignment system. The ability to control and vary the optical coupling is highly desirable in the areas of emerging adaptive optical circuits as well as in ultra-compact tunable, switchable, and reconfigurable optical components and...

Jin Yao

Alumni
Electrical Engineering and Computer Sciences
Professor Ming C. Wu (Advisor)
Ph.D. 2007