Michel M. Maharbiz (Advisor)

Research Advised by Professor Michel M. Maharbiz

B. Arda Ozilgen

Professor Michel M. Maharbiz (Advisor)
Ph.D. 2020

Arda received his B.S. degree in Biomedical Engineering with multiple honors from The Johns Hopkins University with a designated focus in sensors, instrumentation and micro/nanotechnology. His undergraduate research focused on developing scaffolds and instrumentation to promote osteogenic differentiation of human adipose-derived stem cells. As a Vredenburg Scholar, Arda also worked with a group of researchers led by the chair of the Nobel Committee in Physiology or Medicine to uncover the role of diacylglycerol kinase delta in type 2 diabetes pathogenesis. Arda is currently pursuing...

Maharbiz Lab: Tiny Wireless Implant Detects Oxygen Deep within the Body

April 14, 2021

Engineers at the University of California, Berkeley, have created a tiny wireless implant that can provide real-time measurements of tissue oxygen levels deep underneath the skin. The device, which is smaller than the average ladybug and powered by ultrasound waves, could help doctors monitor the health of transplanted organs or tissue and provide an early warning of potential transplant failure.

The technology, created in collaboration with physicians at the University of California, San Francisco, also paves the way for the creation of a variety of miniaturized sensors that could...

BPN844: Wireless Sub-Millimeter Temperature Sensor for Continuous Temperature Monitoring in Tissue

B. Arda Ozilgen

We demonstrate a tetherless, sub-millimeter implantable temperature sensing system employing ultrasonic powering and ultrasonic backscatter modulation assembled using commercially available components. We have demonstrated two sizes of sensors based on available components with volumes of 1.45 mm3 and 0.118 mm3. Individual sensors are able to resolve ±0.5 °C changes in temperature, suitable for medical diagnostic and monitoring purposes. Our goal is to solve a long-standing issue: chronically and tetherlessly monitoring deep tissue temperature.

Project ended: 12/18/...

Fast Detection of Low-Abundance Proteins Based on Ion Concentration Polarization

Bochao Lu

Molecular detection and analysis are of fundamental importance in disease prevention, disease diagnosis, medical treatment, drug delivery, food industry, and environmental monitoring. Conventional immunoassays require hours of incubation for low concentration analytes (femtomolar) since the rate-limiting step is the transport of target molecules to the biosensors. Thus, a new technology for fast and sensitive immunoassay is highly desirable for disease monitoring and personalized treatments. The work reported in this thesis is focused on developing silicon microfabrication technologies for...