Michel M. Maharbiz (Advisor)

Bacterial sensing systems have evolved to detect complex biomolecules, operating near fundamental physical limits for biosensing. No modern engineered biosensor has managed to match the efficiency of bacterial systems, which optimize for each sensing application under constraints on response time and sensitivity. An emerging approach to address this short fallis to build biosensors that electronically couple microbes and devices to combine the sensing capabilities of bacteria with the communication and data processing...

Distributed sensors are becoming ubiquitous in manufacturing, automotive, and consumer applications. One extremely common need at the core of many of these sensors is the requirement to sense small voltages (uV-mV scale), amplify, digitize, and then communicate those bits so they can be acted on. We are taking a different approach - by utilizing nonlinear optical materials, we plan to transduce these signals directly into reflected light, removing the need for complex and high-cost sensor-side circuitry. Since the mechanism is purely passive and does not require a continuous power...

Proton beam therapy is a well-established medical procedure for treating certain kinds of cancer, and is uniquely suited for treatment of head, neck, and eye tumors. Despite the continuous improvements in medical physics treatment plan simulations, improper tissue irradiation can easily occur if there is a shift in the tumor and/or critical organs during the irradiation process. A fully implantable dosimeter for in vivo dose measurements can provide closed loop treatment feedback to a physician during radiation treatments, and assist in enabling full irradiation of a tumor. This work...