Albert P. Pisano (Advisor)

Microfabricated Microneedles for Minimally Invasive Drug Delivery, Sampling and Analysis

Jeffrey Zahn
Dorian Liepmann
Albert P. Pisano
Frank Tendick
2001

Utilizing current Micro Electro Mechanical Systems (MEMS) technologies, different microneedle designs have been fabricated and integrated with various microfabricated microfluidic devices. microneedle technology promises to revolutionize health care by allowing the precise injection of therapeutic agents to prescribed locations below the skin. In addition, microneedles can be used for sample collection for biological analysis, delivery of cell or cellular extract based vaccines, and sample handling providing interconnection between the microscopic and macroscopic world. Microneedsl are...

Micro-Fabricated Shells for Mechanical and Fluidic Interconnects

Phillip Stupar
Albert P. Pisano
Liwei Lin
Luke P. Lee
2001
Three micro-fabricated shell processes are developed in this work, each tailored to a specific application. The first is a two-wafer molding process used to fabricate polysilicon shell suspensions that are very light and stiff. The second is a single crystal silicon...

Phillip Stupar

Alumni
Mechanical Engineering
Professor Albert P. Pisano (Advisor)
Ph.D. 2001

Microfabricated Parylene Microneedles and Pneumatic/Hydraulic Actuators for Use in Interventional, Transvascular Drug Delivery

Kirk Seward
Albert P. Pisano
Kristofer S.J. Pister
Liwei Lin
2001
A method for performing interventional surgery has been developed. Transvascular delivery of therapeutic and diagnostic agents into perivascular space is desirable for various cardiovascular treatments and applications. The dosing of perivascular space requires the perpendicular actuation of a microneedle to slide through the layers...

Kirk Seward

Alumni
Mechanical Engineering
Professor Albert P. Pisano (Advisor)
Ph.D. 2001

Alexandros Papavasiliou

Alumni
Mechanical Engineering
Professor Albert P. Pisano (Advisor)
Ph.D. 2001

Bubble-Actuated Planar Microvalves

Alexandros Papavasiliou
Albert P. Pisano
Dorian Liepmann
Luke P. Lee
2001

This work describes the development of low-power bubble-actuated planar micro gate valves. The work includes the design of the gate valve, the development of electrolysis bubbles as a low power actuator, and a novel fabrication procedure that allows these valves to be integrated with other planar fluidic devices and controlling circuitry. The operation of the valves is demonstrated and valve performance is measured in terms of leakage, power consumption, and cycle time.

The low-power, bubble-actuated, planar micro gate valves consist of a silicon gate that is thrust across a...

Nelson Kuan

Alumni
Mechanical Engineering
Professor Albert P. Pisano (Advisor)
Ph.D. 2001

Kelvin Fu

Alumni
Mechanical Engineering
Professor Albert P. Pisano (Advisor)
Ph.D. 2001

Wyatt Davis

Alumni
Mechanical Engineering
Professor Albert P. Pisano (Advisor)
Ph.D. 2001