We present a mm-sized, ultrasonically powered lensless CMOS image sensor as a progress towards wireless fluorescence microscopy. Access to biological information within the tissue has the potential to provide insights guiding diagnosis and treatment across numerous medical conditions including cancer therapy. This information, in conjunction with current clinical imaging techniques that have limitations in obtaining images continuously and lack wireless compatibility, can improve continual detection of multicell clusters deep within tissue. The proposed platform incorporates a...
Implantable sensors capable of real-time monitoring of complex cellular dynamics can provide critical information for understanding disease progression and treatment response, leading to more personalized medicine. An impactful application is in cancer immunotherapy which produces durable responses but suffers from low response rates (<50%). Multicolor fluorescence microscopy is a critical tool for the study of multi-cell type dynamics but limited optical penetration depth (<5 mm for 400-900nm) and bulky optics constrain its use in vivo. Therefore, wireless, miniaturized...
Real-time monitoring of dynamic biological processes in the body is critical to understanding disease progression and treatment response. These data, for instance, can help address the lower than 50% response rates to cancer immunotherapy. However, current clinical imaging modalities lack the molecular contrast, resolution, and chronic usability for rapid and accurate response assessments. Here, we present a fully wireless image sensor featuring a 2.5 × 5 mm 2 CMOS integrated circuit for multicolor fluorescence imaging deep in tissue. The sensor operates wirelessly via...
In curative-intent cancer surgery, intraoperative fluorescence imaging of both diseased and healthy tissue can help to ensure the successful removal of all gross and microscopic diseases with minimal damage to neighboring critical structures, such as nerves. Current fluorescence-guided surgery (FGS) systems, however, rely on bulky and rigid optics that incur performance-limiting trade-offs between sensitivity and maneuverability. Moreover, many FGS systems are incapable of multiplexed imaging. As a result, clinical FGS is currently limited to millimeter-scale detection of a single...
We present a mm-sized, ultrasonically powered, lensless CMOS image sensor for wireless fluorescence microscopy. Access to real-time cellular-level information within the tissue can provide new insights for diagnosis and personalized treatment guidance across numerous medical conditions including cancer therapy. In cancer immunotherapy, for instance, where a priori identification of responders is challenging, real-time intratumoral information can aid early assessment of treatment response, identifying activation of the immune system leading to durable responses or rapid...
I'm Rozhan Rabbani and I was born in Urmia, Iran. Since Fall 2013, I have studied at Sharif University of Technology, Tehran, Iran. Studying electronics engineering as my main major minored with economics, has broaden my view toward engineering with an economical and managerial perspective. I have done research both on low power biomedical systems and RF design under supervision of renowned electronics professors at Sharif University of Technology. I'd like to pursue my interests in vast research areas of electronics including RF IC Design, Low Power Biomedical Circuits and Wearable...
Mekhail Anwar is an affilated BSAC faculty member and Associate Professor in Residence in the Radiation Oncology Department at UCSF, with an affiliate appointment in our department. Professor Anwar's research areas include many areas within the broad area of electronic circuits and devices.
Dr. Anwar's goal is to solve the fundamental and persistent challenge in cancer – identifying where all tumor cells are and how patients respond to treatment – opening the door to truly precision, personalized medicine. I develop imaging and biosensing tools using...
