Jun-Chau Chien (Advisor)

Research Advised by Professor Jun-Chau Chien

Chien Group:  List of Projects | List of Researchers

BPNX1039: Computational Biosensing with Compute-in-Memory for Aptamer Array

Yu-Chen Chang
2025

Aptamers, often referred to as ""synthetic antibodies,"" are nucleic acid-based molecules that selectively bind to target analytes in complex biological samples, such as whole blood. They can undergo reversible structural changes upon binding, allowing for real-time detection. By conjugating electroactive reporters to aptamers, these structural changes can be monitored electrochemically. Due to their reagentless nature, these biosensors are highly suitable for both in vitro and in vivo applications. Our lab specializes in aptamer-based sensors and has published several studies on their...

Yu-Chen Chang

Visiting Scholar Researcher
Electrical Engineering and Computer Sciences
Professor Jun-Chau Chien (Advisor)
Visiting Scholar 2025

Ya-Chen (Justine) Tsai

Graduate Student Researcher
Electrical Engineering and Computer Sciences
Professor Jun-Chau Chien (Advisor)
Ph.D. 2029 (Anticipated)

Ya-Chen (Justine) Tsai is now a second year PhD student in EECS Department, UC Berkeley. She received her B.S. in National Taiwan University, Department of Electrical Engineering in 2023. Her research interest focuses on CMOS-based microsystems for biosensing, especially the application catered to electrochemical aptamer-based sensing.

BSAC Spring 2024 Research Review Presenter

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Nikhil Jain

Graduate Student Researcher
Electrical Engineering and Computer Sciences
Professor Jun-Chau Chien (Advisor)
Ph.D. 2030 (Anticipated)

Wei-Yu Lin

Graduate Student Researcher
Electrical Engineering and Computer Sciences
Professor Jun-Chau Chien (Advisor)
Ph.D. 2029 (Anticipated)

An RFID-inspired One-step Packaged Multi-mode Bio-analyzer with Vacuum Microfluidics for Point-of-Care Diagnostics

Ya-Chen (Justine) Tsai
2025
Spring 2025 BSAC Research Review Presentation View Slides Project: BPNX1004 - Professor Jun-Chau Chien Group

Hamidreza Afzal

Postdoctoral Researcher
Electrical Engineering and Computer Sciences
Professor Jun-Chau Chien (Advisor)
PostDoc 2025 to present

Hamidreza Afzal (Member, IEEE) received the B.Sc. degree in electrical engineering from the K. N. Toosi University of Technology, Tehran, Iran, in 2015, and the M.S. degree in electrical engineering from the Sharif University of Technology, Tehran, in 2017. He received his Ph.D. degree with the Department of Electrical Engineering, University of California at Davis, Davis, CA, USA in 2024. He is currently a postdoctoral researcher at the University of California, Berkeley. His research interests include radio frequency (RF), millimeter-wave (mm-wave), and terahertz integrated...

Subtractive Microfluidics in CMOS

Wei-Yang Weng
Alexander Di
Xiang Zhang
Ya-Chen (Justine) Tsai
Yan-Ting Hsiao
Jun-Chau Chien
2024

This paper introduces a microfluidics platform embedded within a silicon chip implemented in CMOS technology. The platform utilizes a one-step wet etching method to create fluidic channels by selectively removing CMOS back-end-of-line (BEOL) routing metals. We term our technique “subtractive” microfluidics, to complement those fabricated with additive manufacturing. Three types of structures are presented in a TSMC I80-nm CMOS chip: (1) passive microfluidics in the form of a micro-mixer and a 1: 64 splitter, (2) fluidic channels with embedded ion-sensitive field-effect transistors (ISFETs...

Jun-Chau Chien Receives the Prestigious NSF CAREER Award

December 11, 2024

Jun-Chau Chien

BSAC Co-Director Jun-Chau Chien is the recipient of the NSF CAREER award for his work Chip-Scale Multi-Modal RF-to-Millimeter-Wave Biosensing!

National Science Foundation (NSF) Early Career Development (CAREER) Awards are among the NSF's most prestigious awards in support of the early career-...

Lily Li

Graduate Student Researcher
Electrical Engineering and Computer Sciences
Professor Jun-Chau Chien (Advisor)
Ph.D. 2028 (Anticipated)