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BPN870: Hot Embossed Thermoplastic Bubble-Actuated Micropump

Project ID BPN870
Start Date Mon 2017-Aug-14 15:44:52
Last Updated Sun 2018-Jan-28 11:12:29
Abstract Advances in technology have allowed for development of health diagnostics microdevices, but implementation of microdevices for drug delivery is relatively new. Continuous drug delivery often requires large and complex pumps, making development of micropumps desirable. Similarly, commonly used materials such as silicon, are too expensive for mass production of disposable devices, and polydimethylsiloxane (PDMS) is not compatible with some pharmaceutical drugs due to partitioning effects into the PDMS matrix. Thermoplastic incorporation into microdevices production is more cost efficient compared to silicon and can be tuned to have a variety of chemical, optical, and mechanical properties, in contrast to PDMS. In this research we tested the efficiency of new biosafe drug dispensing microdevice which works with an incorporated micro bubble pump system. The bubble pump system uses electrolysis of water, in which water is broken down into hydrogen and oxygen gas to create a pressure change that displaces a volume of liquid equal to the volume of gas formed. Bubble pumps, unlike mechanical pumps, have no moving parts and are therefore more easily miniaturized. The devices are fabricated using a modified hot embossing method developed by our lab, which allows microelectrodes integration into thermoplastic fluidic channels to create electrolysis chambers. Development of a functional microbubble pump that uses the advantages of thermoplastics will lead to improved development of biosafe drug dispensing microdevices.
Status Continuing
Funding Source BSAC Member Fees
IAB Research Area BioMEMS
Researcher(s) Jackelin Amorin Cotrina, Marc S. Chooljian
Advisor(s) Dorian Liepmann
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