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BPN757: Biosensors Based on Biologically Responsive Polymers

Project ID BPN757
Start Date Tue 2014-May-13 21:21:36
Last Updated Wed 2014-Aug-27 13:41:39
Abstract This project presents the design, fabrication and testing of a novel lab-on-a-chip (LOC) sensor which utilizes a novel stimuli responsive polymer for early detection of circulating reactive oxygen species (ROS) such as hydroperoxides in blood. The portable lab-on-a-chip sensor, termed ROC, is composed of interdigitated electrodes (IDE) coated with a thin film of ROS responsive polymer. ROS leads to cleavage of the cross-linking moiety and degradation of the polymer from the surface of the IDE, and generates a measurable electrical signal that correlates with the amount of hydroperoxides present in the sample. Circulating hydroperoxides mainly lipid hydroperoxides are the primary biomarker of lipid oxidation, which lead to cell damage, inflammation and accumulation of lipid-loaded macrophages, key mediators in development of atherosclerosis. Moreover, circulating lipid hydroperoxides can predict cardiovascular events in patients with a history of cardiovascular diseases. Conventional fluorescence assays to quantify the amount of hydroperoxides in blood are expensive, require advanced instrumentation and have low sensitivity. This technology can be utilized as an accurate, cost-effective, and fast mean of assessing and monitoring lipid hydroperoxides, for effective management of cardiovascular diseases in routine clinical practices.
Status Continuing
Funding Source Federal
IAB Research Area BioMEMS
Researcher(s) Kiana Aran, Jacobo Paredes
Advisor(s) Dorian Liepmann, Niren Murthy
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