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BERKELEY
SENSOR &
ACTUATOR
CENTER
UC
BERKELEY
UC
DAVIS
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(BioPOEMS) Bio-Polymer-Opto-Electro-Microfluidic-System
| Luke Lee, P.I. |
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Program Description:The BioPOEMS interfaces biological molecules or biopolymers with nanoscale probes and biophotonic microsystems. The BioPOEMS allow to create a new paradigm of large-scale hybrid integration of optical, electrical, and microfluidic devices. The BioPOEMS can be exploited in genomic/proteomic chips, point-of-care diagnostic biochips, lab-on-a-chip, or advanced implantable devices. As examples of microscale BioPOEMS, micro-confocal imaging array system ( CIAs), disposable self-aligned integrated microfluidic optical systems (SiMOS), and microarrays of total internal reflection fluorescent microscopy ( TIRFM) on-a-chip are being developed for high-throughput-screening of cellular pathway monitoring. For nanoscale BioPOEMS, nanofluidic Surface-Enhanced Raman Spectroscopy (nSERS) are being developed for single biomolecular detection biochip and direct DNA sequencing. Batch fabrication of plasmon-based nanophotonic devices on transparent substrate with integrated nanocavity junctions is accomplished for compact and ultrasensitive biophotonic nanosystems. | |
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